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Progressive supranuclear palsy

LINC02210-CRHR1 · rs62057121

What the study found

Who was studied 1,718 European ancestry cases, 2,944 European ancestry controls.

The effect Each copy of the A allele shifted the measure 1.32 lower; p = 7 × 10−78.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — in an intron of LINC02210-CRHR1.

What each result means

A/A Two copies of the version the research linked to Progressive supranuclear palsy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Progressive supranuclear palsy. That is a smaller link than two copies.
G/G No copy of the version the research linked to Progressive supranuclear palsy. This is the starting point the study compared everyone against.
Source

Questions about rs62057121

What is rs62057121?

rs62057121 is a single position in the genome, in or near the LINC02210-CRHR1 gene. Published research associates it with progressive supranuclear palsy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs62057121 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62057121 come from?

GWAS Catalog, Molecular neurodegeneration 2024, PMID:39152475. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Progressive supranuclear palsy (rs62057121). MyGeneLog™. https://www.mygenelog.com/variants/rs62057121

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