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Body mass index

FTO · rs62033400

Where this position leads

What the study found

Who was studied 8,463 European ancestry individuals, 7,478 African American individuals, 3,348 Hispanic individuals, 1,624 Han Chinese ancestry individuals; replicated in 4,979 European ancestry individuals, 2,740 Han Chinese ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.08 kg/m2 higher (95% confidence interval 0.060-0.100); p = 2 × 10⁻¹⁴.

Where it sits Chromosome 16, band 16q12.2 — in an intron of FTO.

What each result means

A/A No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Body mass index. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity

Pei YF, Zhang L, Liu Y, Li J, Shen H, Liu YZ, Tian Q, He H, Wu S, Ran S, Han Y, Hai R

and 5 more — show all

Lin Y, Zhu J, Zhu XZ, Papasian CJ, Deng HW

Human molecular genetics · 2014 · PMID 24064335

In the news

2026-04-01 · Portas L, et al., Nature Communications 2026, PMID:41922918

Genetic architecture of sleep in a genome wide association study of device measured sleep traits

Most sleep genetics rests on what people report about their own sleep. This study measured it instead: sleep duration, sleep efficiency, and accelerometer-derived REM and non-REM sleep in 80,013 UK Biobank participants. It found 20 loci, 12 of them not reported before, including genome-wide significant associations for REM and non-REM sleep duration. MEIS1 showed strong opposing effects on REM and non-REM duration. Analysing women and men separately found distinct loci — FOXP2 and NRXN3 in women; LRP1B, NPBWR2 and PABPC4 in men — and Mendelian randomisation supported a link between shorter sleep and higher cardiometabolic risk. The study's MEIS1 position is not in this catalogue; four of its other positions are, including rs2006810 (AUTS2, sleep efficiency) and rs62033400 (FTO, REM sleep duration), which is filed here under body mass index. PMID:41922918.

From our blog

A night of sleep drawn as a band of stages, with the REM portions highlighted

Your Sleep Tracker's REM Minutes Are Partly Inherited: Meet MEIS1

You and your friend slept the same eight hours and your trackers disagree about what happened in them. A 2026 …

Questions about rs62033400

What is rs62033400?

rs62033400 is a single position in the genome, in or near the FTO gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62033400 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs62033400 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62033400 come from?

GWAS Catalog, Hum Mol Genet 2013, PMID:24064335. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs62033400). MyGeneLog™. https://www.mygenelog.com/variants/rs62033400

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