Standard
Lung function (FEV1/FVC)
USP3 · rs62012772
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 321,047 European ancestry individuals; replicated in 79,005 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0288 lower (95% confidence interval 0.023-0.035); p = 2 × 10−20.
How common The T allele had a frequency of about 82% in the people studied.
Where it sits Chromosome 15, band 15q22.31 — in an intron of USP3.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Lung function (FEV1/FVC) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung function (FEV1/FVC).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung function (FEV1/FVC) compared to the general population.
Source
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
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Guyatt AL,
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Jackson VE,
Hobbs BD,
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Batini C,
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Song K,
Sakornsakolpat P,
Li X,
Boxall R
and 99 more — show all
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Nature genetics · 2019 · PMID 30804560 · open access
Questions about rs62012772
What is rs62012772?
rs62012772 is a single position in the genome, in or near the USP3 gene. Published research associates it with lung function (fev1/fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs62012772 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs62012772 come from?
GWAS Catalog, Nature genetics 2019, PMID:30804560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung function (FEV1/FVC) (rs62012772). MyGeneLog™. https://www.mygenelog.com/variants/rs62012772
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