Standard

Immunoglobulin N-glycan 2 levels

near FUT8 · rs61989008

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,020 Korculan or Shetland Isles (founder/genetic isolate) individuals.

The effect Each copy of the T allele shifted the measure 0.702 higher (95% confidence interval 0.55-0.85); p = 2 × 10⁻²⁰.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 14, band 14q23.3 — between genes, 59.6 kb from FUT8.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Immunoglobulin N-glycan 2 levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Immunoglobulin N-glycan 2 levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Immunoglobulin N-glycan 2 levels compared to the general population.

Source

Genetic regulation of post-translational modification of two distinct proteins

Landini A, Trbojević-Akmačić I, Navarro P, Tsepilov YA, Sharapov SZ, Vučković F, Polašek O, Hayward C, Petrović T, Vilaj M, Aulchenko YS, Lauc G

and 2 more — show all

Wilson JF, Klarić L

Nature communications · 2022 · PMID 35332118 · open access

Questions about rs61989008

What is rs61989008?

rs61989008 is a single position in the genome, in or near the near FUT8 gene. Published research associates it with immunoglobulin n-glycan 2 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61989008 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61989008 come from?

GWAS Catalog, Nature communications 2022, PMID:35332118. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Immunoglobulin N-glycan 2 levels (rs61989008). MyGeneLog™. https://www.mygenelog.com/variants/rs61989008

← See all variants