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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 430 Han Chinese ancestry cases, 482 Han Chinese ancestry controls; replicated in 800 Han Chinese ancestry cases, 900 Han Chinese ancestry controls.
The effect
Each copy of the C allele carried 1.51 times the odds of Chronic spontaneous urticaria (95% confidence interval 1.33-1.71); p = 2 × 10−10.
How common The C allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 14, band 14q32.33 — in an intron of IGHA1.
What each result means
C/CTwo copies of the version the research linked to Chronic spontaneous urticaria. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Chronic spontaneous urticaria. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Chronic spontaneous urticaria. This is the starting point the study compared everyone against.
The Journal of investigative dermatology · 2023 · PMID 35933036
Questions about rs61986182
What is rs61986182?
rs61986182 is a single position in the genome, in or near the IGHA1 gene. Published research associates it with chronic spontaneous urticaria. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs61986182 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61986182 come from?
GWAS Catalog, The Journal of investigative dermatology 2023, PMID:35933036. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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