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Body size at age 10

PRKD1 · rs61978655

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²⁰, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 453,169 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0339 lower (95% confidence interval 0.027-0.041); p = 1 × 10⁻²⁰.

How common The G allele had a frequency of about 96% in the people studied.

Where it sits Chromosome 14, band 14q12 — in an intron of PRKD1.

What each result means

A/A No copy of the version the research linked to Body size at age 10. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Body size at age 10. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Body size at age 10. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey Smith G

BMJ (Clinical research ed.) · 2020 · PMID 32376654 · open access

Questions about rs61978655

What is rs61978655?

rs61978655 is a single position in the genome, in or near the PRKD1 gene. Published research associates it with body size at age 10. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61978655 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61978655 come from?

GWAS Catalog, BMJ (Clinical research ed.) 2020, PMID:32376654. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Body size at age 10 (rs61978655). MyGeneLog™. https://www.mygenelog.com/variants/rs61978655

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