Sensitive

Proximal colorectal cancer

RIN3 · rs61975764

Where this position leads

What the study found

Who was studied 15,706 European ancestry cases, 64,159 European ancestry controls.

The effect Each copy of the G allele carried 1.08 times the odds of Proximal colorectal cancer (95% confidence interval 1.05-1.11); p = 3 × 10⁻⁸.

How common The G allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 14, band 14q32.12 — in an intron of RIN3.

What each result means

A/A No copy of the version the research linked to Proximal colorectal cancer. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Proximal colorectal cancer. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Proximal colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA

and 129 more — show all

Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U

Gut · 2021 · PMID 33632709 · open access

Questions about rs61975764

What is rs61975764?

rs61975764 is a single position in the genome, in or near the RIN3 gene. Published research associates it with proximal colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61975764 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs61975764 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61975764 come from?

GWAS Catalog, Gut 2021, PMID:33632709. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Proximal colorectal cancer (rs61975764). MyGeneLog™. https://www.mygenelog.com/variants/rs61975764

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