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Chronotype

MYCBP2 · rs61963491

Where this position leads

Condition: Sleep and Circadian Rhythm

rs61963491 Condition: Sleep and Circadian Rhythm Sleep and Circadian Rhythm Condition rs61963491 rs61963491 MYCBP2

What the study found

Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.101 higher (95% confidence interval 0.079-0.123); p = 4 × 10−19.

How common The A allele had a frequency of about 99% in the people studied.

Where it sits Chromosome 13, band 13q22.3 — between genes, 43.4 kb from MYCBP2.

What each result means

A/A Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Chronotype. That is a smaller link than two copies.
G/G No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.
Source
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H
and 20 more — show all
Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN
Nature communications · 2019 · PMID 30696823 · open access

Questions about rs61963491

What is rs61963491?

rs61963491 is a single position in the genome, in or near the MYCBP2 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61963491 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs61963491 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61963491 come from?

GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronotype (rs61963491). MyGeneLog™. https://www.mygenelog.com/variants/rs61963491

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