Sensitive

Schizophrenia

LINC02730 · rs619091

Where this position leads

Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)

rs619091 Condition: Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk) Autism Spectrum Disorder and Schizo… Condition rs619091 rs619091 LINC02730

What the study found

Who was studied 53,386 European ancestry cases, 77,258 European ancestry controls, 14,004 East Asian ancestry cases, 16,757 East Asian ancestry controls, 6,152 African American cases, 3,918 African American controls, 1,234 Latino cases, 3,090 Latino controls; replicated in 1,979 European ancestry cases, 142,626 European ancestry controls.

The effect Each copy of the A allele carried 0.96 times the odds of Schizophrenia (95% confidence interval 0.94-0.97); p = 2 × 10−9.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 11, band 11q25 — in an intron of LINC02730.

What each result means

A/A Two copies of the version the research linked to Schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Schizophrenia. That is a smaller link than two copies.
T/T No copy of the version the research linked to Schizophrenia. This is the starting point the study compared everyone against.
Source

Questions about rs619091

What is rs619091?

rs619091 is a single position in the genome, in or near the LINC02730 gene. Published research associates it with schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs619091 linked to?

On MyGeneLog this position is linked to Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk). The research behind each link, and its sources, are set out on that condition page.

Does having rs619091 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs619091 come from?

GWAS Catalog, Nature 2022, PMID:35396580. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Schizophrenia (rs619091). MyGeneLog™. https://www.mygenelog.com/variants/rs619091

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