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Allergic disease (asthma, hay fever and/or eczema) (age of onset)

KIRREL3-AS3 · rs61907712

Where this position leads

Condition: Asthma

rs61907712 Condition: Asthma Asthma Condition rs61907712 rs61907712 KIRREL3-AS3

What the study found

Who was studied 117,130 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.034 lower (95% confidence interval 0.024-0.044); p = 2 × 10−10.

How common The C allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 11, band 11q24.3 — between genes, 49.8 kb from LINC02098.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Allergic disease (asthma, hay fever and/or eczema) (age of onset) compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Allergic disease (asthma, hay fever and/or eczema) (age of onset).
G/G Published research associates this genotype with typical/baseline likelihood of Allergic disease (asthma, hay fever and/or eczema) (age of onset) — no copies of the reported risk allele.
Source
Age-of-onset information helps identify 76 genetic variants associated with allergic disease
Ferreira MAR, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, Helmer Q, Tillander A, Ullemar V, Lu Y, Grosche S, Rüschendorf F
and 28 more — show all
Granell R, Brumpton BM, Fritsche LG, Bhatta L, Gabrielsen ME, Nielsen JB, Zhou W, Hveem K, Langhammer A, Holmen OL, Løset M, Abecasis GR, Willer CJ, Emami NC, Cavazos TB, Witte JS, Szwajda A, Hinds DA, Hübner N, Weidinger S, Magnusson PK, Jorgenson E, Karlsson R, Paternoster L, Boomsma DI, Almqvist C, Lee YA, Koppelman GH
23andMe Research Team · collaborators of the SHARE study
PLoS genetics · 2020 · PMID 32603359 · open access

Questions about rs61907712

What is rs61907712?

rs61907712 is a single position in the genome, in or near the KIRREL3-AS3 gene. Published research associates it with allergic disease (asthma, hay fever and/or eczema) (age of onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61907712 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs61907712 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61907712 come from?

GWAS Catalog, PLoS genetics 2020, PMID:32603359. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Allergic disease (asthma, hay fever and/or eczema) (age of onset) (rs61907712). MyGeneLog™. https://www.mygenelog.com/variants/rs61907712

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