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Descending aorta distensibility

PLCE1 · rs61886305

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 29,895 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.05 higher; p = 2 × 10⁻¹⁰.

How common The C allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of PLCE1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Descending aorta distensibility — no copies of the reported risk allele.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Descending aorta distensibility.

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Descending aorta distensibility compared to the general population.

Source

Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities

Francis CM, Futschik ME, Huang J, Bai W, Sargurupremraj M, Teumer A, Breteler MMB, Petretto E, Ho ASR, Amouyel P, Engelter ST, Bülow R

and 11 more — show all

Völker U, Völzke H, Dörr M, Imtiaz MA, Aziz NA, Lohner V, Ware JS, Debette S, Elliott P, Dehghan A, Matthews PM

Nature communications · 2022 · PMID 35922433 · open access

Questions about rs61886305

What is rs61886305?

rs61886305 is a single position in the genome, in or near the PLCE1 gene. Published research associates it with descending aorta distensibility. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61886305 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61886305 come from?

GWAS Catalog, Nature communications 2022, PMID:35922433. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Descending aorta distensibility (rs61886305). MyGeneLog™. https://www.mygenelog.com/variants/rs61886305

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