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Psoriasis

CHUK · rs61871342

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied Up to 11,988 European ancestry cases, up to 275,335 European ancestry controls; replicated in 7,044 European ancestry cases, 11,434 European ancestry controls.

The effect Each copy of the G allele carried 1.10 times the odds of Psoriasis (95% confidence interval -); p = 2 × 10−9.

How common The G allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 10, band 10q24.31 — in an intron of BLOC1S2.

How common each version is

AG
Korean KRGDB
A 16.3% · G 83.7%
Korean Korea4K
A 15.6% · G 84.5%
Japanese ToMMo
A 13.4% · G 86.6%
World gnomAD
A 35.6% · G 64.4%
World 1000 Genomes
A 25.0% · G 75.0%
World TOPMed
A 34.8% · G 65.2%

By ancestry gnomAD

East Asian
A 16.1% · G 83.9%
European (non-Finnish)
A 44.8% · G 55.2%
African / African American
A 23.3% · G 76.7%
South Asian
A 23.2% · G 76.8%
Admixed American (Latino)
A 35.8% · G 64.2%
Middle Eastern
A 39.0% · G 61.0%
Finnish
A 39.7% · G 60.3%
Ashkenazi Jewish
A 33.2% · G 66.8%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

A/A No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Zawistowski M, Ellinghaus E, Barker JN, Chandran V, Dand N, Duffin KC, Enerbäck C
and 26 more — show all
Esko T, Franke A, Gladman DD, Hoffmann P, Kingo K, Kõks S, Krueger GG, Lim HW, Metspalu A, Mrowietz U, Mucha S, Rahman P, Reis A, Reis A, Tejasvi T, Trembath R, Voorhees JJ, Weidinger S, Weichenthal M, Wen X, Eriksson N, Kang HM, Hinds DA, Nair RP, Abecasis GR, Elder JT
Nature communications · 2017 · PMID 28537254 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Psoriasis (rs61871342). MyGeneLog™. https://www.mygenelog.com/variants/rs61871342

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