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Thyroid peroxidase antibody levels in pregnancy

EGR2 · rs61865882

What the study found

Who was studied 60,225 Chinese ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.113 lower (95% confidence interval 0.079-0.146); p = 3 × 10−11.

How common The C allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 10, band 10q21.3 — in the 3′ untranslated region of EGR2.

What each result means

C/C Two copies of the version the research linked to Thyroid peroxidase antibody levels in pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Thyroid peroxidase antibody levels in pregnancy. That is a smaller link than two copies.
T/T No copy of the version the research linked to Thyroid peroxidase antibody levels in pregnancy. This is the starting point the study compared everyone against.
Source

Questions about rs61865882

What is rs61865882?

rs61865882 is a single position in the genome, in or near the EGR2 gene. Published research associates it with thyroid peroxidase antibody levels in pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61865882 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61865882 come from?

GWAS Catalog, Nature communications 2024, PMID:39266554. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyroid peroxidase antibody levels in pregnancy (rs61865882). MyGeneLog™. https://www.mygenelog.com/variants/rs61865882

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