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MSMB protein levels

ALOX5 · rs61855875

Where this position leads

Condition: Celiac Disease

rs61855875 Condition: Celiac Disease Celiac Disease Condition rs61855875 rs61855875 ALOX5

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.259 lower (95% confidence interval 0.23-0.29); p = 3 × 10−81.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 10, band 10q11.21 — in an intron of ALOX5.

What each result means

A/A Two copies of the version the research linked to MSMB protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to MSMB protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to MSMB protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs61855875

What is rs61855875?

rs61855875 is a single position in the genome, in or near the ALOX5 gene. Published research associates it with msmb protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61855875 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs61855875 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61855875 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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MSMB protein levels (rs61855875). MyGeneLog™. https://www.mygenelog.com/variants/rs61855875

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