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Cocaine dependence (time to event)

FAM78B · rs61835088

What the study found

Who was studied 3,554 African American cases, 478 African American controls, 2,712 European ancestry cases, 915 European ancestry controls; replicated in 572 African American cases, 416 African American controls, 759 European ancestry cases, 1,620 European ancestry controls.

The effect Each copy of the T allele carried 0.87 times the odds of Cocaine dependence (time to event); p = 4 × 10−9.

How common The T allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 1, band 1q24.1 — in the 3′ untranslated region of FAM78B.

What each result means

C/C No copy of the version the research linked to Cocaine dependence (time to event). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cocaine dependence (time to event). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cocaine dependence (time to event). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs61835088

What is rs61835088?

rs61835088 is a single position in the genome, in or near the FAM78B gene. Published research associates it with cocaine dependence (time to event). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61835088 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61835088 come from?

GWAS Catalog, Exploration of medicine 2021, PMID:34124712. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cocaine dependence (time to event) (rs61835088). MyGeneLog™. https://www.mygenelog.com/variants/rs61835088

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