Standard
Pulse pressure
LYPLAL1-DT · rs61821643
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,028,980 European ancestry individuals; replicated in 62,047 African ancestry individuals, 21,843 African American individuals.
The effect
Each copy of the C allele shifted the measure 0.456 higher (95% confidence interval 0.31-0.6); p = 3 × 10−10.
Where it sits Chromosome 1, band 1q41 — in an intron of LYPLAL1-DT.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pulse pressure compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pulse pressure.
T/T
Published research associates this genotype with typical/baseline likelihood of Pulse pressure — no copies of the reported risk allele.
Source
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Keaton JM,
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Xie T,
Vaez A,
Williams A,
Goleva SB,
Ani A,
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Hellwege JN,
Yengo L,
Young WJ,
Traylor M
and 135 more — show all
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Nature genetics · 2024 · PMID 38689001 · open access
Questions about rs61821643
What is rs61821643?
rs61821643 is a single position in the genome, in or near the LYPLAL1-DT gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs61821643 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61821643 come from?
GWAS Catalog, Nature genetics 2024, PMID:38689001. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pulse pressure (rs61821643). MyGeneLog™. https://www.mygenelog.com/variants/rs61821643
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