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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 95,472 European ancestry cases, 68,725 European ancestry controls, 23,977 African American cases, 13,387 African American controls, 7,650 Hispanic cases, 7,468 Hispanic controls, 1,088 Asian ancestry cases, 828 Asian ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.111 higher (95% confidence interval 0.074-0.148); p = 3 × 10−9.
How common The A allele had a frequency of about 3% in the people studied.
Where it sits Chromosome 3, band 3q26.2 — in an intron of SLC2A2.
What each result means
A/ATwo copies of the version the research linked to Chronic elevation of alanine aminotransferase (cALT) levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Chronic elevation of alanine aminotransferase (cALT) levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Chronic elevation of alanine aminotransferase (cALT) levels. This is the starting point the study compared everyone against.
rs61791108 is a single position in the genome, in or near the SLC2A2 gene. Published research associates it with chronic elevation of alanine aminotransferase (calt) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs61791108 affect how medicines work?
SLC2A2 carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs61791108 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61791108 come from?
GWAS Catalog, Nature genetics 2022, PMID:35654975. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Chronic elevation of alanine aminotransferase (cALT) levels (rs61791108). MyGeneLog™. https://www.mygenelog.com/variants/rs61791108