Standard
Smoking status (heavy vs never)
LPPR5 · rs61784651
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 24,457 European ancestry heavy smokers, 24,474 European ancestry never smokers.
The effect
Each copy of the T allele carried 1.10 times the odds of Smoking status (heavy vs never) (95% confidence interval 1.07-1.14); p = 3 × 10−8.
How common The T allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 1, band 1p21.3 — in an intron of PLPPR5.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Smoking status (heavy vs never) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking status (heavy vs never).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking status (heavy vs never) compared to the general population.
Source
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Wain LV,
Shrine N,
Miller S,
Jackson VE,
Ntalla I,
Soler Artigas M,
Billington CK,
Kheirallah AK,
Allen R,
Cook JP,
Probert K,
Obeidat M
and 27 more — show all
Bossé Y,
Hao K,
Postma DS,
Paré PD,
Ramasamy A,
Mägi R,
Mihailov E,
Reinmaa E,
Melén E,
O'Connell J,
Frangou E,
Delaneau O,
Freeman C,
Petkova D,
McCarthy M,
Sayers I,
Deloukas P,
Hubbard R,
Pavord I,
Hansell AL,
Thomson NC,
Zeggini E,
Morris AP,
Marchini J,
Strachan DP,
Tobin MD,
Hall IP
The Lancet. Respiratory medicine · 2015 · PMID 26423011 · open access
Questions about rs61784651
What is rs61784651?
rs61784651 is a single position in the genome, in or near the LPPR5 gene. Published research associates it with smoking status (heavy vs never). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs61784651 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61784651 come from?
GWAS Catalog, Lancet Respir Med 2015, PMID:26423011. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants