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Who was studied 62,543 European ancestry individuals (MTAG effective sample size boosted by osteoarthritis, rheumatoid arthritis and endometriosis samples).
The effect
Each copy of the A allele shifted the measure 0.0932 higher (95% confidence interval 0.07-0.117); p = 2 × 10−14.
How common The A allele had a frequency of about 91% in the people studied.
Where it sits Chromosome 1, band 1p21.2 — between genes, 46.8 kb from EXTL2.
What each result means
A/ATwo copies of the version the research linked to Multiple sclerosis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Multiple sclerosis (MTAG). That is a smaller link than two copies.
C/CNo copy of the version the research linked to Multiple sclerosis (MTAG). This is the starting point the study compared everyone against.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs61780263
What is rs61780263?
rs61780263 is a single position in the genome, in or near the near EXTL2 gene. Published research associates it with multiple sclerosis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs61780263 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs61780263 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61780263 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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