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Red cell distribution width

RHCE · rs61777615

Where this position leads

What the study found

Who was studied 116,666 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.04 lower (95% confidence interval 0.032-0.048); p = 3 × 10⁻²⁴.

Where it sits Chromosome 1, band 1p36.11 — in an intron of RHCE.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Red cell distribution width compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Red cell distribution width.

G/G Published research associates this genotype with typical/baseline likelihood of Red cell distribution width — no copies of the reported risk allele.

Source

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Murray A

and 6 more — show all

Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D

PloS one · 2017 · PMID 28957414 · open access

Questions about rs61777615

What is rs61777615?

rs61777615 is a single position in the genome, in or near the RHCE gene. Published research associates it with red cell distribution width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61777615 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs61777615 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61777615 come from?

GWAS Catalog, PLoS One 2017, PMID:28957414. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Red cell distribution width (rs61777615). MyGeneLog™. https://www.mygenelog.com/variants/rs61777615

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