Standard

Initial pursuit acceleration

CYB5R3 · rs61743746

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 114 African ancestry schizophrenia cases, 69 African schizo-affective cases, 41 African ancestry bipolar disorder cases, 76 African ancestry controls, 116 European ancestry schizophrenia cases, 86 European ancestry schizo-affective cases, 165 European ancestry bipolar disorder cases, 182 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 8 × 10⁻¹⁰.

How common The T allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 22, band 22q13.2 — a missense change in CYB5R3.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Initial pursuit acceleration — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Initial pursuit acceleration.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Initial pursuit acceleration compared to the general population.

Source

Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study

Lencer R, Mills LJ, Alliey-Rodriguez N, Shafee R, Lee AM, Reilly JL, Sprenger A, McDowell JE, McCarroll SA, Keshavan MS, Pearlson GD, Tamminga CA

and 4 more — show all

Clementz BA, Gershon ES, Sweeney JA, Bishop JR

Translational psychiatry · 2017 · PMID 29064472 · open access

Questions about rs61743746

What is rs61743746?

rs61743746 is a single position in the genome, in or near the CYB5R3 gene. Published research associates it with initial pursuit acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61743746 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61743746 come from?

GWAS Catalog, Transl Psychiatry 2017, PMID:29064472. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants