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BMI-adjusted waist-hip ratio

CALCRL-AS1 · rs61739909

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 458,317 European ancestry individuals, 138,792 Hispanic or Latin American individuals, 8,948 African ancestry individuals, 2,203 East Asian ancestry individuals, 10,115 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.12 lower (95% confidence interval -0.15--0.08); p = 9 × 10−12.

Where it sits Chromosome 2, band 2q32.1 — a missense change in CALCRL-AS1.

What each result means

A/A No copy of the version the research linked to BMI-adjusted waist-hip ratio. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to BMI-adjusted waist-hip ratio. That is a smaller link than two copies.
G/G Two copies of the version the research linked to BMI-adjusted waist-hip ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes
Akbari P, Sosina OA, Bovijn J, Landheer K, Nielsen JB, Kim M, Aykul S, De T, Haas ME, Hindy G, Lin N, Dinsmore IR
and 48 more — show all
Luo JZ, Hectors S, Geraghty B, Germino M, Panagis L, Parasoglou P, Walls JR, Halasz G, Atwal GS, Jones M, LeBlanc MG, Still CD, Carey DJ, Giontella A, Orho-Melander M, Berumen J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR, Collins R, Rader DJ, Zambrowicz B, Murphy AJ, Balasubramanian S, Overton JD, Reid JG, Shuldiner AR, Cantor M, Abecasis GR, Ferreira MAR, Sleeman MW, Gusarova V, Altarejos J, Harris C, Economides AN, Idone V, Karalis K, Della Gatta G, Mirshahi T, Yancopoulos GD, Melander O, Marchini J, Tapia-Conyer R, Locke AE, Baras A, Verweij N, Lotta LA
Regeneron Genetics Center · DiscovEHR Collaboration
Nature communications · 2022 · PMID 35999217 · open access

Questions about rs61739909

What is rs61739909?

rs61739909 is a single position in the genome, in or near the CALCRL-AS1 gene. Published research associates it with bmi-adjusted waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs61739909 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61739909 come from?

GWAS Catalog, Nature communications 2022, PMID:35999217. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

BMI-adjusted waist-hip ratio (rs61739909). MyGeneLog™. https://www.mygenelog.com/variants/rs61739909

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