FTCD · rs61735836
Where this position leads
Condition: Kidney Function
What the study found
Who was studied 507,850 East Asian ancestry individuals, 420,829 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.021 higher (95% confidence interval 0.016-0.026); p = 9 × 10−16.
Where it sits Chromosome 21, band 21q22.3 — a missense change in FTCD.
What ClinVar records
Classification
Benign for Glutamate formiminotransferase deficiency, FTCD-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2026-01-31.
ClinVar record 340441 NM_206965.2(FTCD):c.301G>A (p.Val101Met)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
2025-09-02 · Tamayo LI et al. Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans. PLoS Genetics 2025, PMID:40892834
Arsenic in drinking water: new genes that change how the body clears it
In Bangladesh more than fifty million people are chronically exposed to arsenic through their drinking water. How well a person breaks arsenic down was already known to depend on the AS3MT and FTCD gene regions; this study of urine from 6,540 people and blood from 976 found new signals in the FMO gene cluster, led by FMO3 and FMO4, and in GSTO1. The new positions did not show a clear association with arsenic-induced skin lesions. Four of the study's positions have pages here, including rs12406572 in FMO3 and rs34521730 in GSTO1. PMID:40892834.
rs61735836 is a single position in the genome, in or near the FTCD gene. Published research associates it with creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2025, PMID:40436827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Creatinine levels (rs61735836). MyGeneLog™. https://www.mygenelog.com/variants/rs61735836