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Ischemic stroke

MARCH1 · rs61734696

Where this position leads

Condition: Ischaemic Stroke

rs61734696 Condition: Ischaemic Stroke Ischaemic Stroke Condition rs61734696 rs61734696 MARCH1

What the study found

Who was studied 450 Japanese ancestry cases, 5,774 Japanese ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 6 × 10−9.

How common The G allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 4, band 4q32.3 — in a non-coding transcript of MARCHF1.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Ischemic stroke compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Ischemic stroke.
T/T Published research associates this genotype with typical/baseline likelihood of Ischemic stroke — no copies of the reported risk allele.
Source
Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage
Yamada Y, Kato K, Oguri M, Horibe H, Fujimaki T, Yasukochi Y, Takeuchi I, Sakuma J
Biomedical reports · 2018 · PMID 29930801 · open access

Questions about rs61734696

What is rs61734696?

rs61734696 is a single position in the genome, in or near the MARCH1 gene. Published research associates it with ischemic stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61734696 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs61734696 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61734696 come from?

GWAS Catalog, Biomed Rep 2018, PMID:29930801. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ischemic stroke (rs61734696). MyGeneLog™. https://www.mygenelog.com/variants/rs61734696

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