Cholesteryl esters to total lipids ratio in small LDL
SIK3 · rs614944
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 115,082 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.105 lower (95% confidence interval 0.074-0.136); p = 3 × 10−11.
How common The T allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — in an intron of SIK3.
What each result means
C/CNo copy of the version the research linked to Cholesteryl esters to total lipids ratio in small LDL. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Cholesteryl esters to total lipids ratio in small LDL. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Cholesteryl esters to total lipids ratio in small LDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs614944 is a single position in the genome, in or near the SIK3 gene. Published research associates it with cholesteryl esters to total lipids ratio in small ldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs614944 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs614944 come from?
GWAS Catalog, PLoS biology 2022, PMID:35213538. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Cholesteryl esters to total lipids ratio in small LDL (rs614944). MyGeneLog™. https://www.mygenelog.com/variants/rs614944