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Basophil forward scatter distribution width

NOL4L · rs6141319

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 30,601 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0523 SD units lower (95% confidence interval 0.035-0.069); p = 1 × 10−9.

How common The G allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 20, band 20q11.21 — in an intron of NOL4L.

What each result means

A/A No copy of the version the research linked to Basophil forward scatter distribution width. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Basophil forward scatter distribution width. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Basophil forward scatter distribution width. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology
Akbari P, Vuckovic D, Stefanucci L, Jiang T, Kundu K, Kreuzhuber R, Bao EL, Collins JH, Downes K, Grassi L, Guerrero JA, Kaptoge S
and 20 more — show all
Knight JC, Meacham S, Sambrook J, Seyres D, Stegle O, Verboon JM, Walter K, Watkins NA, Danesh J, Roberts DJ, Di Angelantonio E, Sankaran VG, Frontini M, Burgess S, Kuijpers T, Peters JE, Butterworth AS, Ouwehand WH, Soranzo N, Astle WJ
Nature communications · 2023 · PMID 37596262 · open access

Questions about rs6141319

What is rs6141319?

rs6141319 is a single position in the genome, in or near the NOL4L gene. Published research associates it with basophil forward scatter distribution width. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6141319 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6141319 come from?

GWAS Catalog, Nature communications 2023, PMID:37596262. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Basophil forward scatter distribution width (rs6141319). MyGeneLog™. https://www.mygenelog.com/variants/rs6141319

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