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Who was studied 656 Chinese ancestry cases, 736 Chinese ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.64 higher (95% confidence interval 0.44-0.84); p = 3 × 10−10.
Where it sits Chromosome 20, band 20p12.3 — between genes, 94.7 kb from RN7SL547P.
What each result means
A/ANo copy of the version the research linked to Late-onset Alzheimer's disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Late-onset Alzheimer's disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Late-onset Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024 · PMID 39023044 · open access
Questions about rs6140401
What is rs6140401?
rs6140401 is a single position in the genome, in or near the near RN7SL547P gene. Published research associates it with late-onset alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6140401 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs6140401 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6140401 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2024, PMID:39023044. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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