Sensitive

Type 2 diabetes

JAG1 · rs6134031

Where this position leads

What the study found

Who was studied 67 Greater Middle Eastern ancestry cases, 214 Greater Middle Eastern ancestry controls; replicated in 1,952 European ancestry cases, 2,960 European ancestry controls.

The effect Each copy of the T allele carried 9.66 times the odds of Type 2 diabetes; p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 20, band 20p12.2 — in an intron of LINC01752.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Type 2 diabetes — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 2 diabetes.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 2 diabetes compared to the general population.

Source

Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations

Dajani R, Li J, Wei Z, March ME, Xia Q, Khader Y, Hakooz N, Fatahallah R, El-Khateeb M, Arafat A, Saleh T, Dajani AR

and 6 more — show all

Al-Abbadi Z, Abdul Qader M, Shiyab AH, Bateiha A, Ajlouni K, Hakonarson H

PeerJ · 2017 · PMID 28828242 · open access

Questions about rs6134031

What is rs6134031?

rs6134031 is a single position in the genome, in or near the JAG1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6134031 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs6134031 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6134031 come from?

GWAS Catalog, PeerJ 2017, PMID:28828242. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants