Sensitive

Colorectal cancer

near LINC01228 · rs61336918

Where this position leads

What the study found

Who was studied 31,197 European ancestry cases, 61,770 European ancestry controls.

The effect Each copy of the A allele carried 1.09 times the odds of Colorectal cancer (95% confidence interval 1.06-1.12); p = 2 × 10⁻¹².

How common The A allele had a frequency of about 29% in the people studied.

Where it sits Chromosome 16, band 16q23.2 — between genes, 146.2 kb from LINC01228.

What each result means

A/A Two copies of the version the research linked to Colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Colorectal cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Colorectal cancer. This is the starting point the study compared everyone against.

Source

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Law PJ, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J, Fernandez-Tajes J, Farrington S, Svinti V, Palles C, Orlando G, Sud A, Holroyd A

and 86 more — show all

Penegar S, Theodoratou E, Vaughan-Shaw P, Campbell H, Zgaga L, Hayward C, Campbell A, Harris S, Deary IJ, Starr J, Gatcombe L, Pinna M, Briggs S, Martin L, Jaeger E, Sharma-Oates A, East J, Leedham S, Arnold R, Johnstone E, Wang H, Kerr D, Kerr R, Maughan T, Kaplan R, Al-Tassan N, Palin K, Hänninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Renkonen-Sinisalo L, Lepistö A, Böhm J, Mecklin JP, Buchanan DD, Win AK, Hopper J, Jenkins ME, Lindor NM, Newcomb PA, Gallinger S, Duggan D, Casey G, Hoffmann P, Nöthen MM, Jöckel KH, Easton DF, Pharoah PDP, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, Harkin A, Allan K, McQueen J, Paul J, Iveson T, Saunders M, Butterbach K, Chang-Claude J, Hoffmeister M, Brenner H, Kirac I, Matošević P, Hofer P, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Tomlinson I, Houlston RS, Dunlop MG

PRACTICAL consortium

Nature communications · 2019 · PMID 31089142 · open access

Questions about rs61336918

What is rs61336918?

rs61336918 is a single position in the genome, in or near the near LINC01228 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs61336918 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs61336918 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs61336918 come from?

GWAS Catalog, Nature communications 2019, PMID:31089142. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colorectal cancer (rs61336918). MyGeneLog™. https://www.mygenelog.com/variants/rs61336918

← See all variants