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Who was studied 388,538 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0139 lower (95% confidence interval 0.0094-0.0184); p = 3 × 10−9.
How common The T allele had a frequency of about 60% in the people studied.
Where it sits Chromosome 20, band 20q13.12 — between genes, 10.1 kb from ZMYND8.
What each result means
G/GNo copy of the version the research linked to Subjective well-being. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Subjective well-being. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Subjective well-being. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2018 · PMID 29292387 · open access
Questions about rs6124977
What is rs6124977?
rs6124977 is a single position in the genome, in or near the near ZMYND8 gene. Published research associates it with subjective well-being. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6124977 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs6124977 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6124977 come from?
GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3528223216Reads by AI crawlersClaude0ChatGPT0Google · Gemini2Perplexity0Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others16Total35Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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