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Urolithiasis

near BCAS1 · rs6123359

Where this position leads

Condition: Urolithiasis

rs6123359 Condition: Urolithiasis Urolithiasis Condition rs6123359 rs6123359 near BCAS1

What the study found

Who was studied 6,223 European ancestry cases, 482,123 European ancestry controls, 11,699 East Asian ancestry cases, 167,027 East Asian ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0998 higher (95% confidence interval 0.074-0.125); p = 2 × 10−14.

Where it sits Chromosome 20, band 20q13.2 — between genes, 27.5 kb from BCAS1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Urolithiasis — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Urolithiasis.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Urolithiasis compared to the general population.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs6123359

What is rs6123359?

rs6123359 is a single position in the genome, in or near the near BCAS1 gene. Published research associates it with urolithiasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6123359 linked to?

On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs6123359 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6123359 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urolithiasis (rs6123359). MyGeneLog™. https://www.mygenelog.com/variants/rs6123359

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