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Its strongest genetic-study result is p = 10−68, with 8 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 2,820 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.202 higher; p = 9 × 10−40.
How common The G allele had a frequency of about 34% in the people studied.
Where it sits Chromosome 9, band 9q34.2 — in an intron of ABO.
What each result means
A/ANo copy of the version the research linked to Metabolic traits. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Metabolic traits. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Metabolic traits. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs612169 is a single position in the genome, in or near the ABO gene. Published research associates it with metabolic traits. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs612169 linked to?
On MyGeneLog this position is linked to Blood Metabolite Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs612169 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs612169 come from?
GWAS Catalog, Nature 2011, PMID:21886157. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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