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Who was studied 3,128 East Asian ancestry cases, 5,493 East Asian ancestry controls.
The effect
Each copy of the C allele carried 1.43 times the odds of Neovascular age-related macular degeneration (95% confidence interval 1.28-1.6); p = 2 × 10−10.
How common The C allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 20, band 20q13.33 — between genes, 0.2 kb from GATA5.
What each result means
C/CTwo copies of the version the research linked to Neovascular age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Neovascular age-related macular degeneration. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Neovascular age-related macular degeneration. This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37696869 · open access
Questions about rs6121609
What is rs6121609?
rs6121609 is a single position in the genome, in or near the near GATA5 gene. Published research associates it with neovascular age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6121609 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does having rs6121609 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6121609 come from?
GWAS Catalog, Nature communications 2023, PMID:37696869. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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