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Asthma

near KIF3B · rs6119231

Where this position leads

Condition: Asthma

rs6119231 Condition: Asthma Asthma Condition rs6119231 rs6119231 near KIF3B

What the study found

Who was studied 71,481 European ancestry cases, 685,602 European ancestry controls.

The effect Each copy of the A allele carried 1.05 times the odds of Asthma (95% confidence interval 1.03-1.062); p = 5 × 10−9.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 20, band 20q11.21 — between genes, 0.9 kb from KIF3B.

What each result means

A/A Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Asthma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
Source
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma
Saarentaus EC, Fischer-Rasmussen K, Sliz E, Bizaki-Vallaskangas A, Laitinen T, Toppila-Salmi S, Kankaanranta H, Kettunen J, Bønnelykke K, Palotie A, Mäkitie A
FinnGen
Nature communications · 2025 · PMID 41213931 · open access

Questions about rs6119231

What is rs6119231?

rs6119231 is a single position in the genome, in or near the near KIF3B gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6119231 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs6119231 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6119231 come from?

GWAS Catalog, Nature communications 2025, PMID:41213931. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs6119231). MyGeneLog™. https://www.mygenelog.com/variants/rs6119231

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