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Who was studied 15,126 European ancestry cases, 95,725 European ancestry controls; replicated in 30,770 European ancestry cases, 286,913 European ancestry controls.
The effect
Each copy of the A allele carried 1.26 times the odds of Restless legs syndrome (95% confidence interval 1.25-1.28); p = 4 × 10−202.
How common The A allele had a frequency of about 59% in the people studied.
Where it sits Chromosome 6, band 6p21.2 — in an intron of BTBD9.
What each result means
A/ATwo copies of the version the research linked to Restless legs syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Restless legs syndrome. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Restless legs syndrome. This is the starting point the study compared everyone against.
The Lancet. Neurology · 2017 · PMID 29029846 · open access
Questions about rs61192259
What is rs61192259?
rs61192259 is a single position in the genome, in or near the BTBD9 gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs61192259 linked to?
On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs61192259 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs61192259 come from?
GWAS Catalog, Lancet Neurol 2017, PMID:29029846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Restless legs syndrome (rs61192259). MyGeneLog™. https://www.mygenelog.com/variants/rs61192259