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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 510,795 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0723 lower (95% confidence interval 0.047-0.098); p = 4 × 10−8.
How common The C allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 20, band 20p11.23 — in an intron of SLC24A3.
What each result means
A/ANo copy of the version the research linked to Noncognitive aspects of educational attainment. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Noncognitive aspects of educational attainment. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Noncognitive aspects of educational attainment. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33414549 · open access
Questions about rs6106115
What is rs6106115?
rs6106115 is a single position in the genome, in or near the SLC24A3 gene. Published research associates it with noncognitive aspects of educational attainment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6106115 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs6106115 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6106115 come from?
GWAS Catalog, Nature genetics 2021, PMID:33414549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Noncognitive aspects of educational attainment (rs6106115). MyGeneLog™. https://www.mygenelog.com/variants/rs6106115