Standard

HDL cholesterol

SEMA3C · rs60839105

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

What the study found

Who was studied 50,823 European ancestry individuals, 703 East Asian ancestry individuals, 6,476 African American individuals, 1,407 Hispanic individuals; replicated in 71,921 European ancestry individuals, 9,992 Indian Asian ancestry individuals, 2,685 African American/Afro-Caribbean individuals.

The effect Each copy of the T allele shifted the measure 2.95 higher (95% confidence interval 1.93-3.96); p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 7, band 7q21.11 — in an intron of SEMA3C.

What each result means

C/C No copy of the version the research linked to HDL cholesterol. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to HDL cholesterol. That is a smaller link than two copies.

T/T Two copies of the version the research linked to HDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB

and 86 more — show all

Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V, Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM, Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Chambers JC, Swertz M, Ripatti S, Willems van Dijk K, Vitart V, Polasek O, Hayward C, Wilson JG, Wilson JF, Gudnason V, Rich SS, Psaty BM, Borecki IB, Boerwinkle E, Rotter JI, Cupples LA, van Duijn CM

LifeLines Cohort Study · CHARGE Lipids Working Group

Journal of medical genetics · 2016 · PMID 27036123 · open access

Questions about rs60839105

What is rs60839105?

rs60839105 is a single position in the genome, in or near the SEMA3C gene. Published research associates it with hdl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs60839105 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs60839105 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60839105 come from?

GWAS Catalog, J Med Genet 2016, PMID:27036123. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

HDL cholesterol (rs60839105). MyGeneLog™. https://www.mygenelog.com/variants/rs60839105

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