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Platelet count

SLC24A3 · rs6081559

Where this position leads

Condition: Blood Cell Counts

rs6081559 Condition: Blood Cell Counts Blood Cell Counts Condition rs6081559 rs6081559 SLC24A3

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 408,112 British individuals.

The effect Each copy of the G allele shifted the measure 0.014 lower (95% confidence interval 0.0094-0.0185); p = 2 × 10−9.

How common The G allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 20, band 20p11.23 — in an intron of SLC24A3.

What each result means

A/A No copy of the version the research linked to Platelet count. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Platelet count. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Platelet count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs6081559

What is rs6081559?

rs6081559 is a single position in the genome, in or near the SLC24A3 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6081559 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs6081559 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6081559 come from?

GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Platelet count (rs6081559). MyGeneLog™. https://www.mygenelog.com/variants/rs6081559

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