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Apolipoprotein A1 levels

TMEM194A · rs60667919

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 393,193 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0135 lower (95% confidence interval 0.0093-0.0177); p = 2 × 10⁻¹⁰.

How common The C allele had a frequency of about 32% in the people studied.

Where it sits Chromosome 12, band 12q13.3 — in an intron of NEMP1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Apolipoprotein A1 levels — no copies of the reported risk allele.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Apolipoprotein A1 levels.

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Apolipoprotein A1 levels compared to the general population.

Source

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV

PLoS medicine · 2020 · PMID 32203549 · open access

Questions about rs60667919

What is rs60667919?

rs60667919 is a single position in the genome, in or near the TMEM194A gene. Published research associates it with apolipoprotein a1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs60667919 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60667919 come from?

GWAS Catalog, PLoS medicine 2020, PMID:32203549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Apolipoprotein A1 levels (rs60667919). MyGeneLog™. https://www.mygenelog.com/variants/rs60667919

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