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Cotinine glucuronidation

KLF4 · rs60634637

Where this position leads

Condition: Nicotine and Cotinine Metabolism

rs60634637 Condition: Nicotine and Cotinine Metabolism Nicotine and Cotinine Metabolism Condition rs60634637 rs60634637 KLF4

What the study found

Who was studied 437 European ancestry current smoker individuals, 364 African American current smoker individuals, 453 Latino current smoker individuals, 674 Japanese ancestry current smoker individuals, 311 Native Hawaiian ancestry current smoker individuals.

The effect Each copy of the T allele shifted the measure 0.0942 higher; p = 2 × 10−8.

Where it sits Chromosome 9, band 9q31.2 — inside LOC105376214.

What each result means

C/C No copy of the version the research linked to Cotinine glucuronidation. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cotinine glucuronidation. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cotinine glucuronidation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs60634637

What is rs60634637?

rs60634637 is a single position in the genome, in or near the KLF4 gene. Published research associates it with cotinine glucuronidation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs60634637 linked to?

On MyGeneLog this position is linked to Nicotine and Cotinine Metabolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs60634637 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60634637 come from?

GWAS Catalog, Cancer Epidemiol Biomarkers Prev 2014, PMID:25293881. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cotinine glucuronidation (rs60634637). MyGeneLog™. https://www.mygenelog.com/variants/rs60634637

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