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Central serous retinopathy

GATA5 · rs6061548

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 610 Japanese ancestry cases, 2,850 Japanese ancestry controls; replicated in 415 Japanese ancestry cases, 6,602 Japanese ancestry controls, 521 European ancestry cases, 3,577 European ancestry controls.

The effect Each copy of the T allele carried 1.63 times the odds of Central serous retinopathy (95% confidence interval 1.44-1.85); p = 5 × 10⁻¹⁵.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 20, band 20q13.33 — between genes, 4.6 kb from GATA5.

What each result means

C/C No copy of the version the research linked to Central serous retinopathy. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Central serous retinopathy. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Central serous retinopathy. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy

Hosoda Y, Miyake M, Schellevis RL, Boon CJF, Hoyng CB, Miki A, Meguro A, Sakurada Y, Yoneyama S, Takasago Y, Hata M, Muraoka Y

and 22 more — show all

Communications biology · 2019 · PMID 31872073 · open access

Questions about rs6061548

What is rs6061548?

rs6061548 is a single position in the genome, in or near the GATA5 gene. Published research associates it with central serous retinopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6061548 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6061548 come from?

GWAS Catalog, Communications biology 2019, PMID:31872073. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Central serous retinopathy (rs6061548). MyGeneLog™. https://www.mygenelog.com/variants/rs6061548

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