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Pentraxin-related protein PTX3 levels

VEPH1 · rs60515336

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.

The effect Each copy of the T allele shifted the measure 0.215 lower; p = 2 × 10−15.

How common The T allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 3, band 3q25.32 — in an intron of VEPH1.

What each result means

C/C No copy of the version the research linked to Pentraxin-related protein PTX3 levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pentraxin-related protein PTX3 levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pentraxin-related protein PTX3 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE
and 71 more — show all
Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A
Nature metabolism · 2020 · PMID 33067605

Questions about rs60515336

What is rs60515336?

rs60515336 is a single position in the genome, in or near the VEPH1 gene. Published research associates it with pentraxin-related protein ptx3 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs60515336 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60515336 come from?

GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pentraxin-related protein PTX3 levels (rs60515336). MyGeneLog™. https://www.mygenelog.com/variants/rs60515336

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