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Insulin fold change during an oral glucose tolerance test

near RN7SKP196 · rs60453193

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 739 East Asian ancestry individuals, 1,099 Hispanic American individuals.

The effect Each copy of the A allele shifted the measure 0.433 higher (95% confidence interval 0.28-0.59); p = 3 × 10⁻⁸.

How common The A allele had a frequency of about 93% in the people studied.

Where it sits Chromosome 10, band 10q21.1 — between genes, 3 kb from RN7SKP196.

What each result means

A/A Two copies of the version the research linked to Insulin fold change during an oral glucose tolerance test. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Insulin fold change during an oral glucose tolerance test. That is a smaller link than two copies.

G/G No copy of the version the research linked to Insulin fold change during an oral glucose tolerance test. This is the starting point the study compared everyone against.

Source

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, Arzumanyan Z, Bonnycastle LL

and 103 more — show all

Bornstein SR, Bretschneider MP, Buchanan TA, Chang YC, Chuang LM, Chung RH, Clausen TD, Damm P, Delgado GE, de Mello VD, Dupuis J, Dwivedi OP, Erdos MR, Fernandes Silva L, Frayling TM, Gieger C, Goodarzi MO, Guo X, Gustafsson S, Hakaste L, Hammar U, Hatem G, Herrmann S, Højlund K, Horn K, Hsueh WA, Hung YJ, Hwu CM, Jonsson A, Kårhus LL, Kleber ME, Kovacs P, Lakka TA, Lauzon M, Lee IT, Lindgren CM, Lindström J, Linneberg A, Liu CT, Luan J, Aly DM, Mathiesen E, Moissl AP, Morris AP, Narisu N, Perakakis N, Peters A, Prasad RB, Rodionov RN, Roll K, Rundsten CF, Sarnowski C, Savonen K, Scholz M, Sharma S, Stinson SE, Suleman S, Tan J, Taylor KD, Uusitupa M, Vistisen D, Witte DR, Walther R, Wu P, Xiang AH, Zethelius B, Ahlqvist E, Bergman RN, Chen YI, Collins FS, Fall T, Florez JC, Fritsche A, Grallert H, Groop L, Hansen T, Koistinen HA, Komulainen P, Laakso M, Lind L, Loeffler M, März W, Meigs JB, Raffel LJ, Rauramaa R, Rotter JI, Schwarz PEH, Stumvoll M, Sundström J, Tönjes A, Tuomi T, Tuomilehto J, Wagner R, Barroso I, Walker M, Grarup N, Boehnke M, Wareham NJ, Mohlke KL, Wheeler E, O'Rahilly S, Fazakerley DJ, Langenberg C

Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)

Nature genetics · 2023 · PMID 37291194 · open access

Questions about rs60453193

What is rs60453193?

rs60453193 is a single position in the genome, in or near the near RN7SKP196 gene. Published research associates it with insulin fold change during an oral glucose tolerance test. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs60453193 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60453193 come from?

GWAS Catalog, Nature genetics 2023, PMID:37291194. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Insulin fold change during an oral glucose tolerance test (rs60453193). MyGeneLog™. https://www.mygenelog.com/variants/rs60453193

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