Sensitive

Small vessel stroke

HTRA1 · rs60401382

Where this position leads

What the study found

Who was studied 423 African American cases, 20,030 African American controls, 5,532 East Asian ancestry cases, 237,242 East Asian ancestry controls, 6,811 European ancestry cases, 1,234,808 European ancestry controls, 207 Hispanic cases, 4,146 Hispanic controls, 647 South Asian ancestry cases, 7,672 South Asian ancestry controls.

The effect Each copy of the C allele carried 1.08 times the odds of Small vessel stroke (95% confidence interval 1.05-1.12); p = 4 × 10⁻⁸.

How common The C allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 10, band 10q26.13 — in an intron of HTRA1.

What each result means

C/C Two copies of the version the research linked to Small vessel stroke. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Small vessel stroke. That is a smaller link than two copies.

T/T No copy of the version the research linked to Small vessel stroke. This is the starting point the study compared everyone against.

Source

Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK

and 175 more — show all

Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Shimizu A, Smith NL, Sloane KL, Sutoh Y, Sun YV, Tanno K, Tiedt S, Tatlisumak T, Torres-Aguila NP, Tiwari HK, Trégouët DA, Trompet S, Tuladhar AM, Tybjærg-Hansen A, van Vugt M, Vibo R, Verma SS, Wiggins KL, Wennberg P, Woo D, Wilson PWF, Xu H, Yang Q, Yoon K, Millwood IY, Gieger C, Ninomiya T, Grabe HJ, Jukema JW, Rissanen IL, Strbian D, Kim YJ, Chen PH, Mayerhofer E, Howson JMM, Irvin MR, Adams H, Wassertheil-Smoller S, Christensen K, Ikram MA, Rundek T, Worrall BB, Lathrop GM, Riaz M, Simonsick EM, Kõrv J, França PHC, Zand R, Prasad K, Frikke-Schmidt R, de Leeuw FE, Liman T, Haeusler KG, Ruigrok YM, Heuschmann PU, Longstreth WT, Jung KJ, Bastarache L, Paré G, Damrauer SM, Chasman DI, Rotter JI, Anderson CD, Zwart JA, Niiranen TJ, Fornage M, Liaw YP, Seshadri S, Fernández-Cadenas I, Walters RG, Ruff CT, Owolabi MO, Huffman JE, Milani L, Kamatani Y, Dichgans M, Debette S

COMPASS Consortium · INVENT Consortium · Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group · Estonian Biobank · PRECISE4Q Consortium · FinnGen Consortium · NINDS Stroke Genetics Network (SiGN) · MEGASTROKE Consortium · SIREN Consortium · China Kadoorie Biobank Collaborative Group · VA Million Veteran Program · International Stroke Genetics Consortium (ISGC) · Biobank Japan · CHARGE Consortium · GIGASTROKE Consortium

Nature · 2022 · PMID 36180795 · open access

Questions about rs60401382

What is rs60401382?

rs60401382 is a single position in the genome, in or near the HTRA1 gene. Published research associates it with small vessel stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs60401382 linked to?

On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.

Does having rs60401382 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60401382 come from?

GWAS Catalog, Nature 2022, PMID:36180795. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Small vessel stroke (rs60401382). MyGeneLog™. https://www.mygenelog.com/variants/rs60401382

← See all variants