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Ischemic stroke

RAP1GAP2 · rs60380775

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 4,307 European ancestry cases, 17,021 European ancestry controls, 884 African American or Afro-Caribbean cases, 6,855 African American or Afro-Caribbean controls, 316 Hispanic or Latin American cases, 2,256 Hispanic or Latin American controls, 80 Asian ancestry cases, 734 Asian ancestry controls, 12 Native American ancestry cases, 34 Native American ancestry controls, 17 cases, 216 controls; replicated in 16,851 European, African American or Afro-Caribbean, Hispanic or Latin American cases, Asian, Native American and unknown ancestry cases, 32,473 European, African American or Afro-Caribbean, Hispanic or Latin American cases, Asian, Native American and unknown ancestry controls.

The effect Each copy of the T allele carried 1.74 times the odds of Ischemic stroke (95% confidence interval 1.4387799772400995-2.115368778899702); p = 2 × 10−8.

Where it sits Chromosome 17, band 17p13.3 — in an intron of RAP1GAP2.

What each result means

C/C No copy of the version the research linked to Ischemic stroke. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Ischemic stroke. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Ischemic stroke. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project
Hu Y, Haessler JW, Manansala R, Wiggins KL, Moscati A, Beiser A, Heard-Costa NL, Sarnowski C, Raffield LM, Chung J, Marini S, Anderson CD
and 27 more — show all
Rosand J, Xu H, Sun X, Kelly TN, Wong Q, Lange LA, Rotter JI, Correa A, Vasan RS, Seshadri S, Rich SS, Do R, Loos RJF, Longstreth WT Jr, Bis JC, Psaty BM, Tirschwell DL, Assimes TL, Silver B, Liu S, Jackson R, Wassertheil-Smoller S, Mitchell BD, Fornage M, Auer PL, Reiner AP, Kooperberg C
Trans-Omics for Precision Medicine (TOPMed) Stroke Working Group, the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Stroke · 2022 · PMID 34727735

Questions about rs60380775

What is rs60380775?

rs60380775 is a single position in the genome, in or near the RAP1GAP2 gene. Published research associates it with ischemic stroke. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs60380775 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60380775 come from?

GWAS Catalog, Stroke 2022, PMID:34727735. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Ischemic stroke (rs60380775). MyGeneLog™. https://www.mygenelog.com/variants/rs60380775

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