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Modified Stumvoll Insulin Sensitivity Index (BMI interaction)

ARHGAP40 · rs6027072

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 16,753 European ancestry individuals; replicated in 13,354 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0184 higher (95% confidence interval 0.0095-0.0273); p = 4 × 10−9.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 20, band 20q11.23 — between genes, 4.4 kb from ARHGAP40.

What each result means

A/A Two copies of the version the research linked to Modified Stumvoll Insulin Sensitivity Index (BMI interaction). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Modified Stumvoll Insulin Sensitivity Index (BMI interaction). That is a smaller link than two copies.
G/G No copy of the version the research linked to Modified Stumvoll Insulin Sensitivity Index (BMI interaction). This is the starting point the study compared everyone against.
Source
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A
and 67 more — show all
Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP, Montasser ME, Landenvall C, Staiger H, Luan J, Frayling TM, Weedon MN, Xie W, Morcillo S, Martínez-Larrad MT, Biggs ML, Chen YD, Corbaton-Anchuelo A, Færch K, Gómez-Zumaquero JM, Goodarzi MO, Kizer JR, Koistinen HA, Leong A, Lind L, Lindgren C, Machicao F, Manning AK, Martín-Núñez GM, Rojo-Martínez G, Rotter JI, Siscovick DS, Zmuda JM, Zhang Z, Serrano-Rios M, Smith U, Soriguer F, Hansen T, Jørgensen TJ, Linnenberg A, Pedersen O, Walker M, Langenberg C, Scott RA, Wareham NJ, Fritsche A, Häring HU, Stefan N, Groop L, O'Connell JR, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, März W, Kovacs P, Stumvoll M, Psaty BM, Kuusisto J, Laakso M, Meigs JB, Dupuis J, Ingelsson E, Florez JC
Diabetes · 2016 · PMID 27416945

Questions about rs6027072

What is rs6027072?

rs6027072 is a single position in the genome, in or near the ARHGAP40 gene. Published research associates it with modified stumvoll insulin sensitivity index (bmi interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6027072 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6027072 come from?

GWAS Catalog, Diabetes 2016, PMID:27416945. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Modified Stumvoll Insulin Sensitivity Index (BMI interaction) (rs6027072). MyGeneLog™. https://www.mygenelog.com/variants/rs6027072

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