FUT2 · rs601338
Where this position leads
Condition: FUT2 Secretor Status
What ClinVar records
Classification
Benign for VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1, SECRETOR/NONSECRETOR POLYMORPHISM, Familial Otitis Media, Bombay phenotype; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2021-08-12.
ClinVar record 12945 NM_000511.6(FUT2):c.461G>A (p.Trp154Ter)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
2026-01-28 · Kamitaki N, et al., Nature 2026, PMID:41606319
Human and bacterial genetic variation shape oral microbiomes and health
The oral microbiomes of 12,519 people were characterised by re-analysing whole-genome sequencing reads from saliva-derived DNA that had already been sequenced for other purposes. Human variation at 11 loci (10 new) associated with oral microbiome composition, several of them about carbohydrate availability. The strongest association by far (P = 3.0 x 10^-188) was the common FUT2 W154X loss-of-function variant — the 'non-secretor' variant, this site's rs601338 on the FUT2 secretor status page — which associated with the abundances of 58 bacterial species. Host genetics also shaped the bacteria's own genomes: the same 11 variants associated with gene-dosage variation in 68 regions of bacterial genomes. Multi-allelic copy number of AMY1, the salivary amylase gene, associated with microbiome composition and with denture use in 418,039 UK Biobank participants, but not with body mass index — suggesting salivary amylase affects health through the mouth's microbes. FUT2 and PITX1 also associated with denture risk, pointing at host-microbe interactions behind tooth decay. PMID:41606319.
rs601338 is a single position in the genome, in or near the FUT2 gene. Published research associates it with secretor status. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to FUT2 Secretor Status. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include vitamins and nutrient levels (2 papers), gut and food intolerance (2 papers), natural selection (1 papers), longevity and ageing (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Kindberg et al. 2007, Journal of General Virology — FUT2 genotype and norovirus susceptibility. PMID 17537929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Secretor status (rs601338). MyGeneLog™. https://www.mygenelog.com/variants/rs601338