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Extensive white matter perivascular space burden

SLC13A3 · rs6011998

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 9,317 European ancestry cases, 29,281 European ancestry controls.

The effect The reported allele is C; the catalogue records no effect size ; p = 2 × 10⁻²⁴.

How common The C allele had a frequency of about 95% in the people studied.

Where it sits Chromosome 20, band 20q13.12 — in an intron of SLC13A3.

What each result means

C/C Two copies of the version the research linked to Extensive white matter perivascular space burden. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Extensive white matter perivascular space burden. That is a smaller link than two copies.

T/T No copy of the version the research linked to Extensive white matter perivascular space burden. This is the starting point the study compared everyone against.

Source

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Duperron MG, Knol MJ, Le Grand Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Trégouët DA, Romero JR, Frenzel S, Luciano M

and 76 more — show all

Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bülow R, Carrera C, Chen C, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang J, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Muñoz Maniega S, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Valdés Hernández MC, Vernooij MW, Völker U, Wittfeld K, Wong TY, Wright MJ, Zhang J, Zhao W, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez-Cadenas I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S

CHARGE consortium

Nature medicine · 2023 · PMID 37069360 · open access

Questions about rs6011998

What is rs6011998?

rs6011998 is a single position in the genome, in or near the SLC13A3 gene. Published research associates it with extensive white matter perivascular space burden. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6011998 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6011998 come from?

GWAS Catalog, Nature medicine 2023, PMID:37069360. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Extensive white matter perivascular space burden (rs6011998). MyGeneLog™. https://www.mygenelog.com/variants/rs6011998

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