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Monocyte percentage of white cells

BACH2 · rs60066732

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−30, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 408,112 British individuals.

The effect Each copy of the G allele shifted the measure 0.0267 higher (95% confidence interval 0.022-0.031); p = 5 × 10−31.

How common The G allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 6, band 6q15 — in an intron of BACH2.

How common each version is

AG
Korean KRGDB
A 88.0% · G 11.9%
Korean Korea4K
A 87.9% · G 12.1%
Korean Korea1K
A 87.5% · G 12.6%
Japanese ToMMo
A 89.0% · G 11.0%
Vietnamese
A 89.7% · G 10.3%
World gnomAD
A 72.9% · G 27.1%
World 1000 Genomes
A 77.3% · G 22.7%
World TOPMed
A 73.0% · G 27.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Monocyte percentage of white cells. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Monocyte percentage of white cells. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Monocyte percentage of white cells. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs60066732

What is rs60066732?

rs60066732 is a single position in the genome, in or near the BACH2 gene. Published research associates it with monocyte percentage of white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs60066732 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs60066732 come from?

GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Monocyte percentage of white cells (rs60066732). MyGeneLog™. https://www.mygenelog.com/variants/rs60066732

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