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Mammographic density (dense area)

MRTFA · rs6001984

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 24,192 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.091 lower (95% confidence interval 0.064-0.118); p = 8 × 10⁻¹¹.

Where it sits Chromosome 22, band 22q13.2 — in an intron of MRTFA.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Mammographic density (dense area) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mammographic density (dense area).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mammographic density (dense area) compared to the general population.

Source

Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk

Sieh W, Rothstein JH, Klein RJ, Alexeeff SE, Sakoda LC, Jorgenson E, McBride RB, Graff RE, McGuire V, Achacoso N, Acton L, Liang RY

and 8 more — show all

Lipson JA, Rubin DL, Yaffe MJ, Easton DF, Schaefer C, Risch N, Whittemore AS, Habel LA

Nature communications · 2020 · PMID 33037222 · open access

Questions about rs6001984

What is rs6001984?

rs6001984 is a single position in the genome, in or near the MRTFA gene. Published research associates it with mammographic density (dense area). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6001984 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6001984 come from?

GWAS Catalog, Nature communications 2020, PMID:33037222. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mammographic density (dense area) (rs6001984). MyGeneLog™. https://www.mygenelog.com/variants/rs6001984

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